IEEE.Fast.Prediction.Of.DNA.Melting.Bubbles.Using.DNA.Thermodynamic.Stability.2015.RETAiL.eBook-KLIP
PACKS________: idib-ffastp
RELEASE DATE_: 2019.09.29
YEAR_________: 2015
LANGUAGE_____: English
RELEASE SIZE_: 0 Mb - 01 files
PAGES________: 9
SOURCE_______: https://ieeexplore.ieee.org/document/7018957
PROTECTION___: -(removed)
FORMAT_______: .pdf
ISBN CODE____: 1545-5963
GENRE________: Scientific Papers
NOTES________: Enjoy
PLOT_________: Abstract: DNA melting bubbles are the basis
of many DNA-protein interactions, such as
those in regulatory DNA regions driving gene
expression, DNA replication and bacterial
horizontal gene transfer. Bubble formation is
affected by DNA duplex stability and
thermally induced duplex destabilization
(TIDD). Although prediction of duplex
stability with the nearest neighbor (NN)
method is much faster than prediction of TIDD
with the Peyrard-Bishop-Dauxois (PBD) model,
PBD predicted TIDD defines regulatory DNA
regions with higher accuracy and detail.
Here, we considered that PBD predicted TIDD
is inherently related to the intrinsic duplex
stabilities of destabilization regions. We
show by regression modeling that NN duplex
stabilities can be used to predict TIDD
almost as accurately as is predicted with
PBD. Predicted TIDD is in fact ascribed to
non-linear transformation of NN duplex
stabilities in destabilization regions as
well as effects of neighboring regions
relative to destabilization size. Since the
prediction time of our models is over six
orders of magnitude shorter than that of PBD,
the models present an accessible tool for
researchers. TIDD can be predicted on our
webserver at http://tidd.immt.eu.
KNOWLEDGE IS POWER